|
|
| Acesso ao texto completo restrito à biblioteca da Embrapa Alimentos e Territórios. Para informações adicionais entre em contato com mara.petrocchi@embrapa.br. |
Registro Completo |
Biblioteca(s): |
Embrapa Alimentos e Territórios. |
Data corrente: |
18/07/2023 |
Data da última atualização: |
16/11/2023 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
BEZERRA, J. N.; GOMEZ, M. C. V.; ROLÓN, M.; CORONEL, C.; ALMEIDA-BEZERRA, J. W.; FIDELIS, K. R.; MENEZES, S. A. de; CRUZ, R. P. da; DUARTE, A. E.; RIBEIRO, P. R. V.; BRITO, E. S. de; COUTINHO, H. D. M.; MORAIS-BRAGA, M. F. B.; BEZERRA, C. F. |
Afiliação: |
JÉSSICA NOGUEIRA BEZERRA, URCA; MARIA CELESTE VEGA GOMEZ, FUNDACIÓN MOISÉS BERTONI; MÍRIAN ROLÓN, FUNDACIÓN MOISÉS BERTONI; CATHIA CORONEL, FUNDACIÓN MOISÉS BERTONI; JOSÉ WEVERTON ALMEIDA-BEZERRA, UFPE; KLEBER RIBEIRO FIDELIS, UFPE; SAULO ALMEIDA DE MENEZES, UFPE; RAFAEL PEREIRA DA CRUZ, URCA; ANTÔNIA ELIENE DUARTE, URCA; PAULO RICELI VASCONCELOS RIBEIRO, CNAT; EDY SOUSA DE BRITO, CNAT; HENRIQUE DOUGLAS MELO COUTINHO, URCA; MARIA FLAVIANA BEZERRA MORAIS-BRAGA, URCA; CAMILA FONSECA BEZERRA, URCA. |
Título: |
Chemical composition, Evaluation of Antiparasitary and Cytotoxic Activity of the essential oil of Psidium brownianum MART EX. DC. |
Ano de publicação: |
2022 |
Fonte/Imprenta: |
Biocatalysis and Agricultural Biotechnology, v. 39, 102247, 2022. |
ISSN: |
1878-8181 |
DOI: |
https://doi.org/10.1016/j.bcab.2021.102247 |
Idioma: |
Inglês |
Conteúdo: |
Chagas Disease and Leishmaniasis are neglected parasitic diseases that constitute a major public health problem. In the search for new therapeutic alternatives for such pathologies, the essential oil of the leaves of Psidium brownianum Mart ex DC was investigated egarding its chemical composition, antiparasitic, and cytotoxic effects. The chemical composition of the oil was analyzed by gas chromatography coupled to mass spectrometry (GC/MS), showing two major constituents: Isogermafurene (52.93%) and Germacrone (16.02%). In antiparasitic activity, the oil was tested against the epimastigote forms of Trypanosoma cruzi, revealing 57.05% inhibition at the highest tested concentration (1000 μg/mL). In regard to antiparasitic activity against promastigote forms of Leishmania braziliensis and ishmania infantum, it obtained 92.61% and 84.16% inhibition, respectively, at the highest concentrations (1000 μg/mL). As for the cytotoxic effects, it showed high cytotoxicity, with IC50 = 328.9 μg/mL. The inhibitory concentration (IC50) obtained the best result for the promastigote forms of L. braziliensis (IC50 = 37.53 μg/mL), as well as the selectivity index (SI = 8.76). Such results generate perspectives for new research and may contribute to more effective drug discoveries. |
Palavras-Chave: |
Anti kinetoplastid; Antiparasitic; Citotóxicos; Doenças parasitárias; Efeito antiparasitário; Parasitic disease; Pathologies; Phytochemistry; Psidium brownianum Mart ex DC; Terapêutica alternativa; Therapeutic alternatives. |
Thesagro: |
Doença de Chagas; Leishmaniose; Myrtaceae; Óleo Vegetal; Saúde Pública. |
Thesaurus Nal: |
Chagas disease; Cytotoxicity; Public health; Vegetable oil. |
Categoria do assunto: |
H Saúde e Patologia |
Marc: |
LEADER 02922naa a2200541 a 4500 001 2155032 005 2023-11-16 008 2022 bl uuuu u00u1 u #d 022 $a1878-8181 024 7 $ahttps://doi.org/10.1016/j.bcab.2021.102247$2DOI 100 1 $aBEZERRA, J. N. 245 $aChemical composition, Evaluation of Antiparasitary and Cytotoxic Activity of the essential oil of Psidium brownianum MART EX. DC.$h[electronic resource] 260 $c2022 520 $aChagas Disease and Leishmaniasis are neglected parasitic diseases that constitute a major public health problem. In the search for new therapeutic alternatives for such pathologies, the essential oil of the leaves of Psidium brownianum Mart ex DC was investigated egarding its chemical composition, antiparasitic, and cytotoxic effects. The chemical composition of the oil was analyzed by gas chromatography coupled to mass spectrometry (GC/MS), showing two major constituents: Isogermafurene (52.93%) and Germacrone (16.02%). In antiparasitic activity, the oil was tested against the epimastigote forms of Trypanosoma cruzi, revealing 57.05% inhibition at the highest tested concentration (1000 μg/mL). In regard to antiparasitic activity against promastigote forms of Leishmania braziliensis and ishmania infantum, it obtained 92.61% and 84.16% inhibition, respectively, at the highest concentrations (1000 μg/mL). As for the cytotoxic effects, it showed high cytotoxicity, with IC50 = 328.9 μg/mL. The inhibitory concentration (IC50) obtained the best result for the promastigote forms of L. braziliensis (IC50 = 37.53 μg/mL), as well as the selectivity index (SI = 8.76). Such results generate perspectives for new research and may contribute to more effective drug discoveries. 650 $aChagas disease 650 $aCytotoxicity 650 $aPublic health 650 $aVegetable oil 650 $aDoença de Chagas 650 $aLeishmaniose 650 $aMyrtaceae 650 $aÓleo Vegetal 650 $aSaúde Pública 653 $aAnti kinetoplastid 653 $aAntiparasitic 653 $aCitotóxicos 653 $aDoenças parasitárias 653 $aEfeito antiparasitário 653 $aParasitic disease 653 $aPathologies 653 $aPhytochemistry 653 $aPsidium brownianum Mart ex DC 653 $aTerapêutica alternativa 653 $aTherapeutic alternatives 700 1 $aGOMEZ, M. C. V. 700 1 $aROLÓN, M. 700 1 $aCORONEL, C. 700 1 $aALMEIDA-BEZERRA, J. W. 700 1 $aFIDELIS, K. R. 700 1 $aMENEZES, S. A. de 700 1 $aCRUZ, R. P. da 700 1 $aDUARTE, A. E. 700 1 $aRIBEIRO, P. R. V. 700 1 $aBRITO, E. S. de 700 1 $aCOUTINHO, H. D. M. 700 1 $aMORAIS-BRAGA, M. F. B. 700 1 $aBEZERRA, C. F. 773 $tBiocatalysis and Agricultural Biotechnology$gv. 39, 102247, 2022.
Download
Esconder MarcMostrar Marc Completo |
Registro original: |
Embrapa Alimentos e Territórios (CNAT) |
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
| Acesso ao texto completo restrito à biblioteca da Embrapa Meio-Norte. Para informações adicionais entre em contato com cpamn.biblioteca@embrapa.br. |
Registro Completo
Biblioteca(s): |
Embrapa Meio-Norte. |
Data corrente: |
06/09/2021 |
Data da última atualização: |
17/11/2021 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 2 |
Autoria: |
CUNHA, J. R. da; FREITAS, R. de C. A. de; SOUZA, D. J. de A. T.; GUALBERTO, A. V. S.; SOUZA, H. A. de; LEITE, L. F. C. |
Afiliação: |
JOÃO RODRIGUES DA CUNHA, Universidade Federal do Piauí, Floriano, Piauí, Brazil.; RITA DE CÁSSIA ALVES DE FREITAS, Instituto Federal de Educação Ciência e Tecnologia do Piauí, São João do Piauí, Piauí, Brazil; DJALMA JUNIOR DE ALMEIDA TAVARES SOUZA, Universidade Federal da Paraíba, Areia, Paraíba, Brazil; ADRIANO VENICIÚS SANTANA GUALBERTO, Universidade Federal do Piauí, Bom Jesus, Piauí, Brazil; HENRIQUE ANTUNES DE SOUZA, CPAMN; LUIZ FERNANDO CARVALHO LEITE, CPAMN. |
Título: |
Soil biological attributes in monoculture and integrated systems in the Cerrado region of Piauí State, Brazil. |
Ano de publicação: |
2021 |
Fonte/Imprenta: |
Acta Scientiarum. Agronomy, v. 43, e51814, 2021. |
Idioma: |
Inglês |
Conteúdo: |
The implementation of integrated agricultural production systems is considered a promising strategy for sustainable agricultural intensification in Brazil. This study aimed to evaluate the effects of different monoculture and integrated production systems on the microbiological attributes and organic carbon of soil from the Cerrado region in Piauí, Brazil. |
Palavras-Chave: |
Biomassa microbiana; Integração pecuária-floresta. |
Thesagro: |
Atividade Enzimática. |
Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
Marc: |
LEADER 01067naa a2200217 a 4500 001 2134095 005 2021-11-17 008 2021 bl uuuu u00u1 u #d 100 1 $aCUNHA, J. R. da 245 $aSoil biological attributes in monoculture and integrated systems in the Cerrado region of Piauí State, Brazil.$h[electronic resource] 260 $c2021 520 $aThe implementation of integrated agricultural production systems is considered a promising strategy for sustainable agricultural intensification in Brazil. This study aimed to evaluate the effects of different monoculture and integrated production systems on the microbiological attributes and organic carbon of soil from the Cerrado region in Piauí, Brazil. 650 $aAtividade Enzimática 653 $aBiomassa microbiana 653 $aIntegração pecuária-floresta 700 1 $aFREITAS, R. de C. A. de 700 1 $aSOUZA, D. J. de A. T. 700 1 $aGUALBERTO, A. V. S. 700 1 $aSOUZA, H. A. de 700 1 $aLEITE, L. F. C. 773 $tActa Scientiarum. Agronomy$gv. 43, e51814, 2021.
Download
Esconder MarcMostrar Marc Completo |
Registro original: |
Embrapa Meio-Norte (CPAMN) |
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
Fechar
|
Nenhum registro encontrado para a expressão de busca informada. |
|
|